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CFL2 / Cofilin 2 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y281 |
| Reactivity | Human, Mouse, Rat, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 19kDa |
| Dilution | ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.01-0.03 µg/ml) |
| Gene ID | 1073 |
|---|---|
| Other Names | Cofilin-2, Cofilin, muscle isoform, CFL2 |
| Target/Specificity | Human CFL2. This antibody is expected to recognise both reported isoforms (NP_068733 and NP_619579) |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CFL2 / Cofilin 2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CFL2 |
|---|---|
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). |
| Cellular Location | Nucleus matrix. Cytoplasm, cytoskeleton. Note=Colocalizes with CSPR3 in the Z line of sarcomeres. |
| Tissue Location | Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
References
Jin J.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Thirion C.,et al.Eur. J. Biochem. 268:3473-3482(2001).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2008) to UniProtKB.
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