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ORC3L / ORC3 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UBD5 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 82kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 23595 |
|---|---|
| Other Names | Origin recognition complex subunit 3, Origin recognition complex subunit Latheo, ORC3, LATHEO, ORC3L |
| Target/Specificity | Human ORC3 / ORC3L. This antibody is expected to recognize both reported isoforms (NP_862820.1 and NP_036513.2). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ORC3L / ORC3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ORC3 |
|---|---|
| Synonyms | LATHEO, ORC3L |
| Function | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. |
| Cellular Location | Nucleus. Chromosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
References
Tugal T.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Dean F.B.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Pinto S.,et al.Neuron 23:45-54(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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