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GPR52 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9Y2T5 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 9293 |
|---|---|
| Other Names | Probable G-protein coupled receptor 52, GPR52 |
| Target/Specificity | Human GPR52 |
| Reconstitution & Storage | Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
| Precautions | GPR52 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508} |
|---|---|
| Function | Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in brain, especially in striatum. |
| Volume | 100 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor.
References
Sawzdargo M.,et al.Brain Res. Mol. Brain Res. 64:193-198(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
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