FMNL1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | O95466 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 122kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 752 |
---|---|
Other Names | Formin-like protein 1, CLL-associated antigen KW-13, Leukocyte formin, FMNL1, C17orf1, C17orf1B, FMNL |
Target/Specificity | Human FMNL1. FRL1 antibody is human, mouse and rat reactive. Three alternatively spliced transcript variants have been observed. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | FMNL1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FMNL1 |
---|---|
Synonyms | C17orf1, C17orf1B, FMNL, FRL1 |
Function | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. |
Cellular Location | Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). |
Tissue Location | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
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Background
May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
References
Favaro P.M.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Krackhardt A.M.,et al.Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
Aronsson F.C.,et al.Hum. Genet. 103:340-345(1998).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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