ZBTB16 / PLZF Antibody (clone 5B3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, ICC, E |
---|---|
Primary Accession | Q05516 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 5B3 |
Calculated MW | 74kDa |
Dilution | ELISA (1:10000), ICC (1:200-1:1000), IF (1:1000), IHC-P (1:50), WB (1:500-1:2000) |
Gene ID | 7704 |
---|---|
Other Names | Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF, ZBTB16, PLZF, ZNF145 |
Target/Specificity | Human PLZF |
Format | Ascitic fluid containing 0.03% sodium azide |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | ZBTB16 / PLZF Antibody (clone 5B3) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZBTB16 |
---|---|
Synonyms | PLZF, ZNF145 |
Function | Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). |
Cellular Location | Nucleus. Nucleus, nuclear body |
Tissue Location | Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung |
Volume | Array |
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Background
Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
References
Chen Z.,et al.EMBO J. 12:1161-1167(1993).
Zhang T.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:11422-11427(1999).
Chen S.-J.,et al.J. Clin. Invest. 91:2260-2267(1993).
Hoatlin M.E.,et al.Blood 94:3737-3747(1999).
Itoh T.,et al.Science 291:1047-1051(2001).
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