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MB / Myoglobin Antibody

Rabbit Polyclonal Antibody

     
  • IHC - MB / Myoglobin Antibody ALS15545
    Anti-Myoglobin antibody IHC of human heart.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P02144
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 17kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 4151
Other Names Myoglobin, MB
Reconstitution & Storage +4°C, avoid freezing
PrecautionsMB / Myoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MB (HGNC:6915)
Function Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218).
Cellular Location Cytoplasm, sarcoplasm
Research Areas
Citations (0)
citation

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Background

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

References

Weller P.,et al.EMBO J. 3:439-446(1984).
Akaboshi E.,et al.Gene 33:241-249(1985).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Dunham I.,et al.Nature 402:489-495(1999).

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$ 555.50
Cat# ALS15545
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