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PEX7 Antibody (aa204-253)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O00628 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36kDa |
| Dilution | ELISA (1:40000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 5191 |
|---|---|
| Other Names | Peroxisomal targeting signal 2 receptor, PTS2 receptor, Peroxin-7, PEX7, PTS2R |
| Target/Specificity | PEX7 Antibody detects endogenous levels of total PEX7 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | PEX7 Antibody (aa204-253) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PEX7 {ECO:0000303|PubMed:9090383, ECO:0000312|HGNC:HGNC:8860} |
|---|---|
| Function | Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (PubMed:11931631, PubMed:22057399, PubMed:25538232, PubMed:9090381). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (PubMed:11931631, PubMed:22057399, PubMed:25538232). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (PubMed:11546814, PubMed:25538232). |
| Cellular Location | Cytoplasm, cytosol. Peroxisome matrix. Note=Translocated into the peroxisome matrix together with PTS2-containing cargo proteins and PEX5 |
| Tissue Location | Ubiquitous (PubMed:9090381). Highest expression in pancreas, skeletal muscle and heart (PubMed:9090381) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
References
Purdue P.E.,et al.Nat. Genet. 15:381-384(1997).
Braverman N.,et al.Nat. Genet. 15:369-376(1997).
Braverman N.,et al.Genomics 63:181-192(2000).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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