CASP10 / Caspase 10 Antibody (aa430-479)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q92851 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 59kDa |
Dilution | ELISA (1:10000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) , |
Gene ID | 843 |
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Other Names | Caspase-10, CASP-10, 3.4.22.63, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, Caspase-10 subunit p23/17, Caspase-10 subunit p12, CASP10, MCH4 |
Target/Specificity | Caspase 10 Antibody detects endogenous levels of total Caspase 10 protein. |
Reconstitution & Storage | Store at -20°C for up to one year. |
Precautions | CASP10 / Caspase 10 Antibody (aa430-479) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CASP10 |
---|---|
Synonyms | MCH4 |
Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr- Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. |
Tissue Location | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon |
Volume | 50 µl |
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Background
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
References
Fernandes-Alnemri T.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:7464-7469(1996).
Vincenz C.,et al.J. Biol. Chem. 272:6578-6583(1997).
Ng P.W.,et al.J. Biol. Chem. 274:10301-10308(1999).
Hadano S.,et al.Genomics 71:200-213(2001).
Vonarbourg C.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
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