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PKMYT1 Antibody (aa49-98)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q99640 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 55kDa |
| Dilution | ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 9088 |
|---|---|
| Other Names | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 2.7.11.1, Myt1 kinase, PKMYT1, MYT1 |
| Target/Specificity | MYT1 (Ab-83) Antibody detects endogenous levels of total MYT1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | PKMYT1 Antibody (aa49-98) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PKMYT1 |
|---|---|
| Synonyms | MYT1 |
| Function | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
References
Booher R.N.,et al.J. Biol. Chem. 272:22300-22306(1997).
Liu F.,et al.Mol. Cell. Biol. 17:571-583(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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