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ACPP / PAP Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P15309 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 45kDa |
| Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 55 |
|---|---|
| Other Names | Prostatic acid phosphatase, PAP, 3.1.3.2, 5'-nucleotidase, 5'-NT, 3.1.3.5, Ecto-5'-nucleotidase, Thiamine monophosphatase, TMPase, PAPf39, ACPP |
| Target/Specificity | Human ACPP. This antibody is expected to recognize both isoforms (NP_001090.2; NP_001127666.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ACPP / PAP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACP3 (HGNC:125) |
|---|---|
| Synonyms | ACPP |
| Function | A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042). |
| Cellular Location | [Isoform 1]: Secreted |
| Tissue Location | Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
References
Sharief F.S.,et al.Biochem. Biophys. Res. Commun. 184:1468-1476(1992).
van Etten R.L.,et al.J. Biol. Chem. 266:2313-2319(1991).
Sharief F.S.,et al.Biochem. Biophys. Res. Commun. 160:79-86(1989).
Vihko P.,et al.FEBS Lett. 236:275-281(1988).
Tailor P.G.,et al.Nucleic Acids Res. 18:4928-4928(1990).
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