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CAV3 / Caveolin 3 Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P56539 |
| Reactivity | Human, Monkey, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 17kDa |
| Dilution | ELISA (1:4000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 859 |
|---|---|
| Other Names | Caveolin-3, M-caveolin, CAV3 |
| Target/Specificity | Human CAV3 / Caveolin 3. Reported variants represent identical protein (NP_001225.1; NP_203123.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CAV3 / Caveolin 3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAV3 |
|---|---|
| Function | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564). |
| Cellular Location | Golgi apparatus membrane; Peripheral membrane protein. Cell membrane {ECO:0000250|UniProtKB:P51638}; Peripheral membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:P51637}; Peripheral membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P51637}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity) |
| Tissue Location | Expressed predominantly in muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
References
Minetti C.,et al.Nat. Genet. 18:365-368(1998).
Biederer C.,et al.Biochim. Biophys. Acta 1406:5-9(1998).
McNally E.M.,et al.Hum. Mol. Genet. 7:871-877(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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