CREB1 / CREB Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | P16220 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 37kDa |
Dilution | IHC-P (5 µg/ml), WB (0.5-4 µg/ml), |
Gene ID | 1385 |
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Other Names | Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1 |
Target/Specificity | Rat CREB1 / CREB |
Reconstitution & Storage | Store at -20°C. |
Precautions | CREB1 / CREB Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CREB1 |
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Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312, ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12552083} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
References
Berkowitz L.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5258-5262(1990).
Yoshimura T.,et al.EMBO J. 9:2537-2542(1990).
Waeber G.,et al.Trans. Assoc. Am. Physicians 103:28-37(1990).
Hoeffler J.P.,et al.Science 242:1430-1433(1988).
Short M.L.,et al.Nucleic Acids Res. 19:4290-4290(1991).
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