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B2M / Beta 2 Microglobulin Antibody (clone B2M-01)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP, RIA, FC |
|---|---|
| Primary Accession | P61769 |
| Reactivity | Human, Mouse, Rabbit, Chicken, Bovine, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | B2M-01 |
| Calculated MW | 14kDa |
| Dilution | IHC-P (1:50), WB (2-4 µg/ml), |
| Gene ID | 567 |
|---|---|
| Other Names | Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M |
| Target/Specificity | reacts with beta2-microglobulin (b2M) associated with cell-surfaceMHC Class I molecules and other membrane antigens as well as with solublebeta2-microglobulin. b2M is a 12 kDa Ig like glycoprotein expressed on lymphocytes,thymocytes, monocytes, granu ... |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | B2M / Beta 2 Microglobulin Antibody (clone B2M-01) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | B2M (HGNC:914) |
|---|---|
| Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). |
| Cellular Location | Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
References
Guessow D.,et al.J. Immunol. 139:3132-3138(1987).
He X.H.,et al.Sheng Wu Gong Cheng Xue Bao 20:99-103(2004).
Matsumoto K.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Tan J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zhao Z.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
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