KCNJ11 / Kir6.2 Antibody (aa190-239)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q14654 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 44kDa |
Dilution | ELISA (1:10000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) , |
Gene ID | 3767 |
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Other Names | ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11, KCNJ11 |
Target/Specificity | Kir6.2 Antibody detects endogenous levels of total Kir6.2 protein. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | KCNJ11 / Kir6.2 Antibody (aa190-239) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KCNJ11 |
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Function | This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. |
Cellular Location | Membrane; Multi-pass membrane protein. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
References
Inagaki N.,et al.Science 270:1166-1170(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Babenko A.P.,et al.Circ. Res. 83:1132-1143(1998).
Ribalet B.,et al.Biophys. J. 84:266-276(2003).
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