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SNCB / Beta-Synuclein Antibody (aa85-134)

Rabbit Polyclonal Antibody

     
  • IF - SNCB / Beta-Synuclein Antibody (aa85-134) ALS15068
    Immunofluorescence of A549 cells, using Synuclein beta Antibody.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q16143
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 14kDa
Dilution ELISA (1:5000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 6620
Other Names Beta-synuclein, SNCB
Target/Specificity Synuclein beta Antibody detects endogenous levels of total Synuclein beta protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSNCB / Beta-Synuclein Antibody (aa85-134) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNCB
Function Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Cellular Location Cytoplasm.
Tissue Location Expressed predominantly in brain; concentrated in presynaptic nerve terminals
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

References

Jakes R.,et al.FEBS Lett. 345:27-32(1994).
Lavedan C.,et al.Genomics 54:173-175(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.

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$ 467.50
Cat# ALS15068
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