EPB41L4B Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q9H329 |
Reactivity | Human, Rabbit, Monkey, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 100kDa |
Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), |
Gene ID | 54566 |
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Other Names | Band 4.1-like protein 4B, FERM-containing protein CG1, Protein EHM2, EPB41L4B, EHM2 |
Target/Specificity | Human EPB41L4B. This antibody is expected to recognise both reported isoforms (NP_060894.2; NP_061987.3). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | EPB41L4B Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EPB41L4B (HGNC:19818) |
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Function | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid- induced cell differentiation (PubMed:14521927). |
Cellular Location | Cytoplasm. Cell junction, tight junction Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner. |
Tissue Location | Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927) |
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Provided below are standard protocols that you may find useful for product applications.
References
Chadwick B.P.,et al.Mamm. Genome 11:81-83(2000).
Shimizu K.,et al.Genomics 65:113-120(2000).
Humphray S.J.,et al.Nature 429:369-374(2004).
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