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CEACAM5 / CD66e Antibody (clone CB30)

Mouse Monoclonal Antibody

     
  • IHC - CEACAM5 / CD66e Antibody (clone CB30) ALS14924
    Anti-CEA antibody IHC of human colon.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, IP, IHC-F, FC
Primary Accession P06731
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names CB30
Calculated MW 77kDa
Dilution IHC-Fr, IHC-P (10 µg/ml),
Additional Information
Gene ID 1048
Other Names Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen, CEA, Meconium antigen 100, CD66e, CEACAM5, CEA
Target/Specificity Recognizes human CD66e, also known as carcinoembryonic antigen (CEA). CD66e is a member of the immunoglobulin supergene family that is mainly expressed on epithelial cells. CD66e may play a role in cancer cells metastasis, and has been used clinicall ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCEACAM5 / CD66e Antibody (clone CB30) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEACAM5
Synonyms CEA
Function Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface Note=Localized to the apical glycocalyx surface
Tissue Location Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Research Areas
Citations (0)
citation

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Background

Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

References

Beauchemin N.,et al.Mol. Cell. Biol. 7:3221-3230(1987).
Barnett T.,et al.Genomics 3:59-66(1988).
Schrewe H.,et al.Mol. Cell. Biol. 10:2738-2748(1990).
Grimwood J.,et al.Nature 428:529-535(2004).
Oikawa S.,et al.Biochem. Biophys. Res. Commun. 142:511-518(1987).

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$ 467.50
Cat# ALS14924
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