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REG3A Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • IHC - REG3A Antibody (aa1-50) ALS14905
    Anti-REG3A antibody IHC of human small intestine.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q06141
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 19kDa
Dilution IHC-P (10 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 5068
Other Names Regenerating islet-derived protein 3-alpha, REG-3-alpha, Hepatointestinal pancreatic protein, HIP/PAP, Human proislet peptide, Pancreatitis-associated protein 1, Regenerating islet-derived protein III-alpha, Reg III-alpha, Regenerating islet-derived protein 3-alpha 16.5 kDa form, Regenerating islet-derived protein 3-alpha 15 kDa form, REG3A, HIP, PAP, PAP1
Target/Specificity Human REG3A
Reconstitution & Storage Store at 4°C, stable for 6 months. For long term storage, aliquot and store at -20°C.
PrecautionsREG3A Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name REG3A (HGNC:8601)
Function [Regenerating islet-derived protein 3-alpha 15 kDa form]: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan (PubMed:16931762). Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore (PubMed:24256734).
Cellular Location Secreted. Note=Found in the apical region of pancreatic acinar cells
Tissue Location Expressed by keratinocytes (PubMed:27830702). Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level) (PubMed:22727489). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis (PubMed:1469087).
Research Areas
Citations (0)
citation

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Background

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.

References

Itoh T.,et al.Biochim. Biophys. Acta 1172:184-186(1993).
Orelle B.,et al.J. Clin. Invest. 90:2284-2291(1992).
Lasserre C.,et al.Cancer Res. 52:5089-5095(1992).
Dusetti N.J.,et al.Genomics 19:108-114(1994).
Lasserre C.,et al.Eur. J. Biochem. 224:29-38(1994).

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$ 467.50
Cat# ALS14905
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