NF-L / NEFL Antibody (clone 2F11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F |
---|---|
Primary Accession | P07196 |
Reactivity | Human, Opossum |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2F11 |
Calculated MW | 62kDa |
Dilution | IHC-Fr (1:25-1:200), IHC-P (10 µg/ml), WB (1:100-1:1000) |
Gene ID | 4747 |
---|---|
Other Names | Neurofilament light polypeptide, NF-L, 68 kDa neurofilament protein, Neurofilament triplet L protein, NEFL, NF68, NFL |
Target/Specificity | Reacts exclusively with the phosphorylated isoform of the70 kD neurofilament protein. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | NF-L / NEFL Antibody (clone 2F11) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NEFL |
---|---|
Synonyms | NF68, NFL |
Function | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). |
Cellular Location | Cell projection, axon {ECO:0000250|UniProtKB:P08551}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08551} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
References
Julien J.-P.,et al.Biochim. Biophys. Acta 909:10-20(1987).
Perez-Olle R.,et al.J. Cell Sci. 115:4937-4946(2002).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Pospelov V.A.,et al.Cell Growth Differ. 5:187-196(1994).
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