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Ferritin Heavy Chain / FTH1 Antibody (clone 3F8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P02794 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3F8 |
| Calculated MW | 21kDa |
| Dilution | IHC-P (1:200), WB (1:1000), |
| Gene ID | 2495 |
|---|---|
| Other Names | Ferritin heavy chain, Ferritin H subunit, 1.16.3.1, Cell proliferation-inducing gene 15 protein, Ferritin heavy chain, N-terminally processed, FTH1, FTH, FTHL6 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | Ferritin Heavy Chain / FTH1 Antibody (clone 3F8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FTH1 |
|---|---|
| Synonyms | FTH, FTHL6 |
| Function | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293). |
| Cellular Location | Cytoplasm. Lysosome. Cytoplasmic vesicle, autophagosome |
| Tissue Location | Expressed in the liver. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
References
Costanzo F.,et al.EMBO J. 3:23-27(1984).
Boyd D.,et al.J. Biol. Chem. 260:11755-11761(1985).
Chou C.-C.,et al.Mol. Cell. Biol. 6:566-573(1986).
Costanzo F.,et al.Nucleic Acids Res. 14:721-736(1986).
Hentze M.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:7226-7230(1986).
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