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HPN / TMPRSS1 / Hepsin Antibody

Rabbit Polyclonal Antibody

     
  • IHC - HPN / TMPRSS1 / Hepsin Antibody ALS14692
    Anti-HPN / Hepsin antibody IHC of human liver.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P05981
Reactivity Human, Rabbit, Monkey, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Dilution IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 3249
Other Names Serine protease hepsin, 3.4.21.106, Transmembrane protease serine 1, Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain, HPN, TMPRSS1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHPN / TMPRSS1 / Hepsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPN
Synonyms TMPRSS1
Function Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, PubMed:21875933). Plays a role in cell growth and maintenance of cell morphology (PubMed:21875933, PubMed:8346233). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Cellular Location Cell membrane; Single-pass type II membrane protein Apical cell membrane; Single-pass type II membrane protein
Tissue Location Detected in liver and kidney.
Volume 100 µl
Research Areas
Citations (0)
citation

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Background

Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.

References

Leytus S.P.,et al.Biochemistry 27:1067-1074(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tsuji A.,et al.J. Biol. Chem. 266:16948-16953(1991).
Torres-Rosado A.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:7181-7185(1993).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).

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$ 467.50
Cat# ALS14692
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