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HNRPA1 / HnRNP A1 Antibody (aa51-100)

Rabbit Polyclonal Antibody

     
  • IF - HNRPA1 / HnRNP A1 Antibody (aa51-100) ALS14623
    Immunofluorescence of HeLa cells, using hnRNP A1 Antibody.
    detail
  • IHC - HNRPA1 / HnRNP A1 Antibody (aa51-100) ALS14623
    Anti-HNRNPA1 / HnRNP A1 antibody IHC of human small intestine.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P09651
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Dilution ELISA (1:20000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 3178
Other Names Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1
Target/Specificity hnRNP A1 Antibody detects endogenous levels of total hnRNP A1 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHNRPA1 / HnRNP A1 Antibody (aa51-100) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNRNPA1
Synonyms HNRPA1
Function Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233).
Cellular Location Nucleus. Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661) Nucleus. Note=(Microbial infection) SARS coronavirus-2/SARS-CoV-2 ORF6 protein increases accumulation to the nucleus.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.

References

Biamonti G.,et al.J. Mol. Biol. 207:491-503(1989).
Buvoli M.,et al.Nucleic Acids Res. 16:3751-3770(1988).
Knudsen S.M.,et al.Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 467.50
Cat# ALS14623
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