PRUNE Antibody (clone 1C11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q86TP1 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 1C11 |
Calculated MW | 50kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 58497 |
---|---|
Other Names | Protein prune homolog, hPrune, 3.6.1.1, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE |
Target/Specificity | Human PRUNE |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | PRUNE Antibody (clone 1C11) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PRUNE1 (HGNC:13420) |
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Synonyms | PRUNE |
Function | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). |
Cellular Location | Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed |
Tissue Location | Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
References
Reymond A.,et al.Oncogene 18:7244-7252(1999).
Zollo M.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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