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NTN1 / Netrin 1 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O95631 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Monkey, Xenopus, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 68kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.5-1.5 µg/ml) |
| Gene ID | 9423 |
|---|---|
| Other Names | Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L |
| Target/Specificity | Human NTN1 / Netrin 1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | NTN1 / Netrin 1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NTN1 |
|---|---|
| Synonyms | NTN1L |
| Function | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). |
| Cellular Location | Secreted. Cytoplasm. Note=Mainly secreted |
| Tissue Location | Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
References
Meyerhardt J.A.,et al.Cell Growth Differ. 10:35-42(1999).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L.,et al.Nature 431:80-84(2004).
Liu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).
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