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NOS3 / eNOS Antibody (aa1181-1194)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P29474 |
| Reactivity | Human, Rabbit, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 133kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 4846 |
|---|---|
| Other Names | Nitric oxide synthase, endothelial, 1.14.13.39, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII, NOS3 |
| Target/Specificity | Recognizes eNOS/NOS III, Mr ~135kD. Species cross-reactivity: Human and bovine. Predicted to cross-react with mouse, guinea pig, porcine, rat and canine based on sequence homology. |
| Reconstitution & Storage | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C |
| Precautions | NOS3 / eNOS Antibody (aa1181-1194) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOS3 (HGNC:7876) |
|---|---|
| Function | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. |
| Cellular Location | Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity |
| Tissue Location | Platelets, placenta, liver and kidney. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
References
Janssens S.P.,et al.J. Biol. Chem. 267:14519-14522(1992).
Janssens S.P.,et al.J. Biol. Chem. 267:22694-22694(1992).
Marsden P.A.,et al.FEBS Lett. 307:287-293(1992).
Marsden P.A.,et al.J. Biol. Chem. 268:17478-17488(1993).
Nadaud S.A.,et al.Biochem. Biophys. Res. Commun. 198:1027-1033(1994).
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