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KLF11 Antibody (clone 10D8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | O14901 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 10D8 |
| Calculated MW | 55kDa |
| Dilution | IF (10 µg/ml), IHC-P (10 µg/ml), |
| Gene ID | 8462 |
|---|---|
| Other Names | Krueppel-like factor 11, Transforming growth factor-beta-inducible early growth response protein 2, TGFB-inducible early growth response protein 2, TIEG-2, KLF11, FKLF, TIEG2 |
| Target/Specificity | Human KLF11 |
| Reconstitution & Storage | Store at -20°C, avoid freeze thaw cycles. |
| Precautions | KLF11 Antibody (clone 10D8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLF11 |
|---|---|
| Synonyms | FKLF, TIEG2 |
| Function | Transcription factor (PubMed:10207080, PubMed:9748269). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:10207080, PubMed:16131492, PubMed:9748269). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. Higher expression in erythroid cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
References
Cook T.,et al.J. Biol. Chem. 273:25929-25936(1998).
Asano H.,et al.Mol. Cell. Biol. 19:3571-3579(1999).
Scohy S.,et al.Genomics 70:93-101(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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