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Alpha-1-Antichymotrypsin Antibody (clone 1E6)

Mouse Monoclonal Antibody

     
  • WB - Alpha-1-Antichymotrypsin Antibody (clone 1E6) ALS14015
    Western blot of SERPINA3 expression in transfected 293T cell line by SERPINA3 monoclonal...
    detail
  • IP - Alpha-1-Antichymotrypsin Antibody (clone 1E6) ALS14015
    Immunoprecipitation of SERPINA3 transfected lysate using anti-SERPINA3 monoclonal antibody and...
    detail
  • IHC - Alpha-1-Antichymotrypsin Antibody (clone 1E6) ALS14015
    Anti-SERPINA3 antibody IHC of human adrenal.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession P01011
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1E6
Calculated MW 48kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 12
Other Names Alpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24/25 protein, Serpin A3, Alpha-1-antichymotrypsin His-Pro-less, SERPINA3, AACT
Target/Specificity Human SERPINA3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsAlpha-1-Antichymotrypsin Antibody (clone 1E6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINA3
Synonyms AACT
Function Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Cellular Location Secreted.
Tissue Location Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Research Areas
Citations (0)
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Background

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

References

Chandra T.,et al.Biochemistry 22:5055-5061(1983).
Poller W.,et al.Genomics 17:740-743(1993).
Kim J.W.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 533.50
Cat# ALS14015
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