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COMT Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P21964 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 30kDa |
| Dilution | ELISA (1:4000), IHC-P (3.75 µg/ml), WB (1:4000) |
| Gene ID | 1312 |
|---|---|
| Other Names | Catechol O-methyltransferase, 2.1.1.6, COMT |
| Target/Specificity | Human COMT. This antibody is expected to recognise both reported isoforms. Variants (NP_000745.1; NP_001128633.1; NP_001128634.1) encode the same isoform. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | COMT Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COMT (HGNC:2228) |
|---|---|
| Function | Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
| Cellular Location | [Isoform Soluble]: Cytoplasm |
| Tissue Location | Brain, liver, placenta, lymphocytes and erythrocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
References
Lundstroem K.,et al.DNA Cell Biol. 10:181-189(1991).
Bertocci B.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991).
Tenhunen J.,et al.Eur. J. Biochem. 223:1049-1059(1994).
Li J.Y.,et al.Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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