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TLR3 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | O15455 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 104kDa |
| Dilution | IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:1000-1:10000) |
| Gene ID | 7098 |
|---|---|
| Other Names | Toll-like receptor 3, CD283, TLR3 |
| Target/Specificity | Human TLR3. Predicted cross-reactivity based on amino acid sequence homology: mouse (81%), guinea pig (84%), rat (83%), rabbit (82%), bovine (86%), cat (86%), pig (84%), monkey (96%). |
| Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Precautions | TLR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLR3 (HGNC:11849) |
|---|---|
| Function | Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome |
| Tissue Location | Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons |
| Volume | 100 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
References
Rock F.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998).
Lafon M.,et al.J. Mol. Neurosci. 29:185-194(2006).
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Macquin C.,et al.Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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