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CD79A Antibody (clone HM57)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, FC |
|---|---|
| Primary Accession | P11912 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Chicken, Opossum, Horse, Bovine, Guinea Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | HM57 |
| Calculated MW | 25kDa |
| Dilution | IHC-Fr, IHC-P (15 µg/ml), |
| Gene ID | 973 |
|---|---|
| Other Names | B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD79a, CD79A, IGA, MB1 |
| Target/Specificity | The antibody HM57 interacts with CD79a (Ig alpha), a 40-45 kD subunit of B cell antigen-specific receptor (BCR) and its early developmental forms. HLDA V; WS Code BC cB018. HLDA VI; WS Code BP 193. HLDA VI; WS Code BP 89. HLDA VI; WS Code B B103. HLD ... |
| Reconstitution & Storage | +4°C, avoid freezing |
| Precautions | CD79A Antibody (clone HM57) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD79A |
|---|---|
| Synonyms | IGA, MB1 |
| Function | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B- cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. |
| Tissue Location | B-cells. |
Provided below are standard protocols that you may find useful for product applications.
Background
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
References
Leduc I.,et al.Clin. Exp. Immunol. 90:141-146(1992).
Mueller B.S.,et al.Eur. J. Immunol. 22:1621-1625(1992).
Flaswinkel H.,et al.Immunogenetics 36:266-269(1992).
Yu L.M.,et al.J. Immunol. 148:633-637(1992).
Ha H.J.,et al.J. Immunol. 148:1526-1531(1992).
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