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Kinesin Heavy Chain / KIF5B Antibody (clone KN-03)

Mouse Monoclonal Antibody

     
  • IHC - Kinesin Heavy Chain / KIF5B Antibody (clone KN-03) ALS13468
    Anti-KIF5B antibody IHC of human heart.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC
Primary Accession P33176
Reactivity Human, Mouse, Rat, Pig
Host Mouse
Clonality Monoclonal
Clone Names KN-03
Calculated MW 110kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3799
Other Names Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC, KIF5B, KNS, KNS1
Target/Specificity Recognizes heavy chain of conventional kinesin associated with vesicles and with lower affinity with denatured molecule. It stains Western blots of kinesin-enriched preparations. Epitope mapping (by limited proteolysis of partially purified porcine k ...
Reconstitution & Storage Store at 4°C. Do not freeze.
PrecautionsKinesin Heavy Chain / KIF5B Antibody (clone KN-03) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIF5B (HGNC:6324)
Synonyms KNS, KNS1
Function Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2PQA9}. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250|UniProtKB:Q2PQA9}
Research Areas
Citations (0)
citation

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Background

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.

References

Navone F.,et al.J. Cell Biol. 117:1263-1275(1992).
Deloukas P.,et al.Nature 429:375-381(2004).
Su Q.,et al.Nat. Cell Biol. 6:941-953(2004).
Boucrot E.,et al.Science 308:1174-1178(2005).
Olsen J.V.,et al.Cell 127:635-648(2006).

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$ 467.50
Cat# ALS13468
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