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PTPN11 / SHP-2 / NS1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - PTPN11 / SHP-2 / NS1 Antibody (C-Terminus) ALS13396
    Anti-PTPN11 antibody IHC of human brain, cerebellum.
    detail
  • IHC - PTPN11 / SHP-2 / NS1 Antibody (C-Terminus) ALS13396
    Anti-PTPN11 antibody IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q06124
Reactivity Human, Rabbit, Monkey, Chicken, Horse, Xenopus, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 68kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 5781
Other Names Tyrosine-protein phosphatase non-receptor type 11, 3.1.3.48, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2
Target/Specificity Human PTPN11.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPTPN11 / SHP-2 / NS1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN11
Synonyms PTP2C, SHPTP2
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884).
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

References

Adachi M.,et al.FEBS Lett. 314:335-339(1992).
Freeman R.M. Jr.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:11239-11243(1992).
Bastien L.,et al.Biochem. Biophys. Res. Commun. 196:124-133(1993).
Ahmad S.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:2197-2201(1993).
Vogel W.,et al.Science 259:1611-1614(1993).

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$ 467.50
Cat# ALS13396
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