IRF4 Antibody (clone 2F2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q15306 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2F2 |
Calculated MW | 52kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 3662 |
---|---|
Other Names | Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1 |
Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | IRF4 Antibody (clone 2F2) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IRF4 |
---|---|
Synonyms | MUM1 |
Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Lymphoid cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
References
Grossman A.,et al.Genomics 37:229-233(1996).
Iida S.,et al.Nat. Genet. 17:226-230(1997).
Mungall A.J.,et al.Nature 425:805-811(2003).
Rao S.,et al.J. Biol. Chem. 274:11115-11124(1999).
Gupta S.,et al.Hum. Immunol. 64:389-401(2003).
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