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EYA4 Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O95677 |
| Reactivity | Human, Rabbit, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 70kDa |
| Dilution | ELISA (1:128000), IHC-P (3.75 µg/ml), |
| Gene ID | 2070 |
|---|---|
| Other Names | Eyes absent homolog 4, 3.1.3.48, EYA4 |
| Target/Specificity | Human EYA4. This antibody is expected to recognise isoforms a, c and d (NP_004091.3, NP_742102.1 and NP_742103.1 respectively). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | EYA4 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EYA4 |
|---|---|
| Function | Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99502}. Nucleus {ECO:0000250|UniProtKB:Q99502} |
| Tissue Location | Highly expressed in heart and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).
References
Borsani G.,et al.Hum. Mol. Genet. 8:11-23(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Wayne S.,et al.Hum. Mol. Genet. 10:195-200(2001).
Schoenberger J.,et al.Nat. Genet. 37:418-422(2005).
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