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MMP3 Antibody

Rabbit Polyclonal Antibody

     
  • WB - MMP3 Antibody ALS13311
    Western blot of MMP-3 antibody ALS13311.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P08254
Reactivity Human, Mouse, Rat, Rabbit, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 54kDa
Dilution IHC-P (5 µg/ml), WB (0.5-4 µg/ml),
Additional Information
Gene ID 4314
Other Names Stromelysin-1, SL-1, 3.4.24.17, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1
Target/Specificity The antibody recognizes the MMP-3 of human, mouse, rat, horse, and rabbit origins. Reactivity to other species has not been tested. The antibody detects the 55 kD full length and the 21 kD cleavage fragment of MMP-3.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsMMP3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP3
Synonyms STMY1
Function Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 (PubMed:11029580, PubMed:1371271). Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway (PubMed:2383557). Acts also intracellularly (PubMed:22265821). For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha- synuclein/SNCA cleavage (PubMed:21330369). In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311).
Cellular Location Secreted, extracellular space, extracellular matrix. Nucleus. Cytoplasm
Research Areas
Citations (0)
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Background

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

References

Saus J.,et al.J. Biol. Chem. 263:6742-6745(1988).
Whitham S.E.,et al.Biochem. J. 240:913-916(1986).
Wilhelm S.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6725-6729(1987).
Lin D.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 467.50
Cat# ALS13311
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