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CTSK / Cathepsin K Antibody (clone 2F1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P43235 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2F1 |
| Calculated MW | 37kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 1513 |
|---|---|
| Other Names | Cathepsin K, 3.4.22.38, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2 |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | CTSK / Cathepsin K Antibody (clone 2F1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTSK |
|---|---|
| Synonyms | CTSO, CTSO2 |
| Function | Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042). |
| Cellular Location | Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells |
| Tissue Location | Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
References
Shi G.-P.,et al.FEBS Lett. 357:129-134(1995).
Inaoka T.,et al.Biochem. Biophys. Res. Commun. 206:89-96(1995).
Li Y.,et al.J. Bone Miner. Res. 10:1197-1202(1995).
Broemme D.,et al.Biol. Chem. Hoppe-Seyler 376:379-384(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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