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HNE / Neutrophil Elastase Antibody
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E, IE |
|---|---|
| Primary Accession | P08246 |
| Reactivity | Human |
| Host | Sheep |
| Clonality | Polyclonal |
| Calculated MW | 29kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 1991 |
|---|---|
| Other Names | Neutrophil elastase, 3.4.21.37, Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2 |
| Target/Specificity | Specific for elastase. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | HNE / Neutrophil Elastase Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ELANE |
|---|---|
| Synonyms | ELA2 |
| Function | Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed:36899106). Promotes blood coagulation (PubMed:20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed:25211214, PubMed:9111081). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (PubMed:20676107, PubMed:25211214). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). |
| Cellular Location | Cytoplasmic vesicle, phagosome. Note=Localized in phagolysosomes following ingestion of E.coli by neutrophils |
| Tissue Location | Bone marrow cells. Neutrophil (PubMed:10947984). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
References
Nakamura H.,et al.Nucleic Acids Res. 15:9601-9601(1987).
Takahashi H.,et al.J. Biol. Chem. 263:14739-14747(1988).
Farley D.,et al.Biol. Chem. Hoppe-Seyler 370:737-744(1989).
Okano K.,et al.Biochem. Biophys. Res. Commun. 167:1326-1332(1990).
Okano K.,et al.J. Biochem. 102:13-16(1987).
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