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VRL1 / TRPV2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9Y5S1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 86kDa |
| Dilution | IHC-P (10 µg/ml), WB (1:500-1:3000), |
| Gene ID | 51393 |
|---|---|
| Other Names | Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1, TRPV2, VRL |
| Target/Specificity | Human and mouse VRL1. |
| Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Precautions | VRL1 / TRPV2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPV2 |
|---|---|
| Synonyms | VRL |
| Function | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9WTR1}; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9WTR1}. Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV {ECO:0000250|UniProtKB:Q9WTR1} |
| Volume | 100 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
References
Caterina M.J.,et al.Nature 398:436-441(1999).
Garcia R.L.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Kelsell R.E.,et al.Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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