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ETS1 / ETS-1 Antibody (clone 8A8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E, FC |
|---|---|
| Primary Accession | P14921 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8A8 |
| Calculated MW | 50kDa |
| Dilution | Flo (1:200-1:400), IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000) , |
| Gene ID | 2113 |
|---|---|
| Other Names | Protein C-ets-1, p54, ETS1, EWSR2 |
| Target/Specificity | Human ETS1 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ETS1 / ETS-1 Antibody (clone 8A8) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ETS1 |
|---|---|
| Synonyms | EWSR2 |
| Function | Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). |
| Cellular Location | Nucleus. Cytoplasm Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. |
| Tissue Location | Highly expressed within lymphoid cells. Isoforms c- ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
References
Reddy E.S.P.,et al.Oncogene Res. 3:239-246(1988).
Watson D.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7862-7866(1988).
Laitem C.,et al.Oncogene 28:2087-2099(2009).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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