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GPI Antibody (clone 1B7D7)

Mouse Monoclonal Antibody

     
  • WB - GPI Antibody (clone 1B7D7) ALS13147
    Western blot using GPI mouse monoclonal antibody against HEK293T cells transfected with the...
    detail
  • IF - GPI Antibody (clone 1B7D7) ALS13147
    Confocal immunofluorescence of L-02 cells using GPI mouse monoclonal antibody (green).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P06744
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B7D7
Calculated MW 63kDa
Dilution ELISA (1:10000), IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000) ,
Additional Information
Gene ID 2821
Other Names Glucose-6-phosphate isomerase, GPI, 5.3.1.9, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI, Sperm antigen 36, SA-36, GPI
Target/Specificity Human GPI
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGPI Antibody (clone 1B7D7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPI {ECO:0000303|PubMed:2387591, ECO:0000312|HGNC:HGNC:4458}
Function In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745).
Cellular Location Cytoplasm. Secreted
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

References

Gurney M.E.,et al.Submitted (MAR-1987) to the EMBL/GenBank/DDBJ databases.
Yakirevich E.,et al.Biol. Reprod. 62:1016-1023(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Walker J.I.H.,et al.Genomics 7:638-643(1990).

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$ 467.50
Cat# ALS13147
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