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Fc Epsilon RI / FcERI Antibody (clone AER-37 (CRA1))
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, FC |
|---|---|
| Primary Accession | P12319 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | AER-37 (CRA1) |
| Calculated MW | 30kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 2205 |
|---|---|
| Other Names | High affinity immunoglobulin epsilon receptor subunit alpha, Fc-epsilon RI-alpha, FcERI, IgE Fc receptor subunit alpha, FCER1A, FCE1A |
| Reconstitution & Storage | Store at 4°C, avoid repeated freeze thaw cycles. |
| Precautions | Fc Epsilon RI / FcERI Antibody (clone AER-37 (CRA1)) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCER1A |
|---|---|
| Synonyms | FCE1A |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in eosinophils. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
References
Kochan J.,et al.Nucleic Acids Res. 16:3584-3584(1988).
Shimizu A.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:1907-1911(1988).
Yagi S.,et al.Eur. J. Biochem. 220:593-598(1994).
Padlan E.A.,et al.Receptor 2:129-144(1992).
Garman S.C.,et al.Cell 95:951-961(1998).
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