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CCR4 Antibody (Extracellular Domain)

Goat Polyclonal Antibody

     
  • IHC - CCR4 Antibody (Extracellular Domain) ALS13112
    Anti-CCR4 antibody IHC of human pancreas.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, FC
Primary Accession P51679
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 41kDa
Dilution ELISA (1:30000), Flo (1:12), IHC-P (5 µg/ml), WB (1:500) ,
Additional Information
Gene ID 1233
Other Names C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5, CD194, CCR4, CMKBR4
Target/Specificity Peptide sequence is <50% identical to other chemokine receptors in this region.
Reconstitution & Storage Long term: -70°C; Short term: -20°C; Avoid freeze-thaw cycles.
PrecautionsCCR4 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR4
Synonyms CMKBR4
Function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells (PubMed:10754297).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

References

Power C.A.,et al.J. Biol. Chem. 270:19495-19500(1995).
Kato H.,et al.Genes Immun. 1:97-104(1999).
Kopatz S.A.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Imai T.,et al.J. Biol. Chem. 272:15036-15042(1997).
Imai T.,et al.J. Biol. Chem. 273:1764-1768(1998).

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$ 467.50
Cat# ALS13112
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