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CCR4 Antibody (Extracellular Domain)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, FC |
|---|---|
| Primary Accession | P51679 |
| Reactivity | Human, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | ELISA (1:30000), Flo (1:12), IHC-P (5 µg/ml), WB (1:500) , |
| Gene ID | 1233 |
|---|---|
| Other Names | C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5, CD194, CCR4, CMKBR4 |
| Target/Specificity | Peptide sequence is <50% identical to other chemokine receptors in this region. |
| Reconstitution & Storage | Long term: -70°C; Short term: -20°C; Avoid freeze-thaw cycles. |
| Precautions | CCR4 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCR4 |
|---|---|
| Synonyms | CMKBR4 |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells (PubMed:10754297). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
References
Power C.A.,et al.J. Biol. Chem. 270:19495-19500(1995).
Kato H.,et al.Genes Immun. 1:97-104(1999).
Kopatz S.A.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Imai T.,et al.J. Biol. Chem. 272:15036-15042(1997).
Imai T.,et al.J. Biol. Chem. 273:1764-1768(1998).
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