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CLEC2D / OCIL / LLT1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9UHP7 |
| Reactivity | Human, Monkey, Horse |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 22kDa |
| Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), |
| Gene ID | 29121 |
|---|---|
| Other Names | C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, LLT-1, Osteoclast inhibitory lectin, CLEC2D, CLAX, LLT1, OCIL |
| Target/Specificity | Human CLEC2D. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CLEC2D / OCIL / LLT1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLEC2D |
|---|---|
| Synonyms | CLAX, LLT1, OCIL |
| Function | Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:16339513, PubMed:20843815). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein [Isoform 4]: Endoplasmic reticulum |
| Tissue Location | Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.
References
Boles K.S.,et al.Immunogenetics 50:1-7(1999).
Hu Y.S.,et al.J. Bone Miner. Res. 19:89-99(2004).
Germain C.,et al.J. Biol. Chem. 285:36207-36215(2010).
Yang G.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
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