SCD1 / SCD Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | O00767 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 42kDa |
Dilution | ELISA (1:64000), IHC-P (5 µg/ml), |
Gene ID | 6319 |
---|---|
Other Names | Acyl-CoA desaturase, 1.14.19.1, Delta(9)-desaturase, Delta-9 desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase, SCD |
Target/Specificity | Human SCD. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | SCD1 / SCD Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SCD |
---|---|
Function | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:18765284, ECO:0000305} |
Tissue Location | Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
References
Al-Jeryan L.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Zhang L.,et al.Biochem. J. 340:255-264(1999).
Hoshino T.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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