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GOT2 Antibody (clone 3E9)

Mouse Monoclonal Antibody

     
  • IF - GOT2 Antibody (clone 3E9) ALS13052
    Immunofluorescence of PC-3 (left) and SK-BR-3 (right) cells using anti-GOT2 monoclonal antibody...
    detail
  • IHC - GOT2 Antibody (clone 3E9) ALS13052
    Anti-GOT2 antibody IHC of human brain, cortex.
    detail
  • IHC - GOT2 Antibody (clone 3E9) ALS13052
    Anti-GOT2 antibody IHC of human liver.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P00505
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 3E9
Calculated MW 48kDa
Dilution ELISA (1:10000), IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000) ,
Additional Information
Gene ID 2806
Other Names Aspartate aminotransferase, mitochondrial, mAspAT, 2.6.1.1, 2.6.1.7, Fatty acid-binding protein, FABP-1, Glutamate oxaloacetate transaminase 2, Kynurenine aminotransferase 4, Kynurenine aminotransferase IV, Kynurenine--oxoglutarate transaminase 4, Kynurenine--oxoglutarate transaminase IV, Plasma membrane-associated fatty acid-binding protein, FABPpm, Transaminase A, GOT2
Target/Specificity Human GOT2
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGOT2 Antibody (clone 3E9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GOT2 (HGNC:4433)
Function Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
Cellular Location Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

References

Pol S.,et al.Biochem. Biophys. Res. Commun. 157:1309-1315(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Martin J.,et al.Nature 432:988-994(2004).
Martini F.,et al.Biochim. Biophys. Acta 832:46-51(1985).

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$ 467.50
Cat# ALS13052
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