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GOT2 Antibody (clone 3E9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P00505 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3E9 |
| Calculated MW | 48kDa |
| Dilution | ELISA (1:10000), IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000) , |
| Gene ID | 2806 |
|---|---|
| Other Names | Aspartate aminotransferase, mitochondrial, mAspAT, 2.6.1.1, 2.6.1.7, Fatty acid-binding protein, FABP-1, Glutamate oxaloacetate transaminase 2, Kynurenine aminotransferase 4, Kynurenine aminotransferase IV, Kynurenine--oxoglutarate transaminase 4, Kynurenine--oxoglutarate transaminase IV, Plasma membrane-associated fatty acid-binding protein, FABPpm, Transaminase A, GOT2 |
| Target/Specificity | Human GOT2 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GOT2 Antibody (clone 3E9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GOT2 (HGNC:4433) |
|---|---|
| Function | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. |
| Cellular Location | Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
References
Pol S.,et al.Biochem. Biophys. Res. Commun. 157:1309-1315(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Martin J.,et al.Nature 432:988-994(2004).
Martini F.,et al.Biochim. Biophys. Acta 832:46-51(1985).
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