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ALB / Serum Albumin Antibody (clone 2H3D1;8F6F9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P02768 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2H3D1;8F6F9 |
| Calculated MW | 69kDa |
| Dilution | ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000) |
| Gene ID | 213 |
|---|---|
| Other Names | Serum albumin, ALB |
| Target/Specificity | human albumin |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ALB / Serum Albumin Antibody (clone 2H3D1;8F6F9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALB |
|---|---|
| Function | Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). |
| Cellular Location | Secreted. |
| Tissue Location | Plasma. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
References
Lawn R.M.,et al.Nucleic Acids Res. 9:6103-6114(1981).
Dugaiczyk A.,et al.Proc. Natl. Acad. Sci. U.S.A. 79:71-75(1982).
Minghetti P.P.,et al.J. Biol. Chem. 261:6747-6757(1986).
Yang S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Huang M.C.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
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