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BDNF Antibody

Goat Polyclonal Antibody

     
  • IHC - BDNF Antibody ALS12984
    Anti-BDNF antibody IHC of human brain, cortex.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P23560
Reactivity Human, Mouse, Rat, Hamster, Monkey, Pig, Horse, Bovine, Guinea Pig, Dog
Host Goat
Clonality Polyclonal
Calculated MW 28kDa
Dilution IHC-P (3.75 µg/ml)
Additional Information
Gene ID 627
Other Names Brain-derived neurotrophic factor, BDNF, Abrineurin, BDNF
Target/Specificity Human BDNF. This antibody is expected to recognise all reported isoforms (NP_001700.2; NP_001700.2; NP_733928.1; NP_733929.1; NP_733930.1; NP_733931.1)
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsBDNF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BDNF {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:1033}
Function Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Cellular Location Secreted
Tissue Location Detected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta
Research Areas
Citations (0)
citation

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Background

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

References

Jones K.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990).
Maisonpierre P.C.,et al.Genomics 10:558-568(1991).
Shintani A.,et al.Biochem. Biophys. Res. Commun. 182:325-332(1992).
Liu Q.-R.,et al.Am. J. Med. Genet. B Neuropsychiatr. Genet. 134:93-103(2005).
Pruunsild P.,et al.Genomics 90:397-406(2007).

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$ 467.50
Cat# ALS12984
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