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CASP12 / Caspase 12 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q6UXS9 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39kDa |
| Dilution | IHC-P (5 µg/ml), WB (0.5-2 µg/ml), |
| Gene ID | 100506742 |
|---|---|
| Other Names | Inactive caspase-12, CASP-12, CASP12 |
| Target/Specificity | synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | CASP12 / Caspase 12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CASP12 |
|---|---|
| Function | May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF (PubMed:15129283). May lack protease activity (Probable). |
| Tissue Location | Widely expressed, with highest levels in lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
References
Fischer H.,et al.Biochem. Biophys. Res. Commun. 293:722-726(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).
Saleh M.,et al.Nature 429:75-79(2004).
Kachapati K.,et al.Hum. Mutat. 27:975-975(2006).
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