CRADD / RAIDD Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | P78560 |
Reactivity | Human, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 23kDa |
Dilution | IHC-P (10 µg/ml), WB (1:500), |
Gene ID | 8738 |
---|---|
Other Names | Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD |
Target/Specificity | Detects an ~24 kD protein, corresponding to the apparent molecular mass of RAIDD on SDS-PAGE immunoblots. This 24 kD band, as well as a 67 kD band, can be specifically inhibited by the relevant peptide. |
Reconstitution & Storage | Store at -20°C. |
Precautions | CRADD / RAIDD Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CRADD |
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Synonyms | RAIDD |
Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:9044836). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O88843}. Nucleus {ECO:0000250|UniProtKB:O88843} |
Tissue Location | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
References
Ahmad M.,et al.Cancer Res. 57:615-619(1997).
Duan H.,et al.Nature 385:86-89(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Tinel A.,et al.Science 304:843-846(2004).
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