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ROR1 Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q01973 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 104kDa |
| Dilution | IHC-P (3-6 µg/ml) |
| Gene ID | 4919 |
|---|---|
| Other Names | Tyrosine-protein kinase transmembrane receptor ROR1, 2.7.10.1, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1 |
| Target/Specificity | Human ROR1. This antibody is expected to recognize isoform 1 (NP_005003.2) only. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ROR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ROR1 |
|---|---|
| Synonyms | NTRKR1 |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068). |
| Cellular Location | Membrane; Single- pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z139} |
| Tissue Location | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Tyrosine-protein kinase receptor whose role is not yet clear.
References
Masiakowski P.,et al.J. Biol. Chem. 267:26181-26190(1992).
Reddy U.R.,et al.Oncogene 13:1555-1559(1996).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Sjoeblom T.,et al.Science 314:268-274(2006).
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